PHR1703

ナタマイシン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: ピマリシン, ナタマイシン
• 実験式（ヒル表記法）: C₃₃H₄₇NO₁₃
• CAS番号: 7681-93-8
• 分子量: 665.73
• EC Number: 231-683-5
• MDL番号: MFCD00135085
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823566
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1457505
• APIファミリー: natamycin
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: -10 to -25°C
• SMILES記法: C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O1)C[C@H](O)[C@H]2C(O)=O)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O
• InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
• InChI Key: NCXMLFZGDNKEPB-FFPOYIOWSA-N

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Natamycin is a major drug that is utilized in the treatment of fungal keratitis. It is, by far, the only available approved antifungal drug for the said purpose by the U.S. Food and Drug Administration.

アプリケーション

Natamycin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high-performance liquid chromatography coupled with tandem mass spectrometry (LC−MS/MS).

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

エルゴステロールに特異的に結合してカビの生育を阻止する抗カビポリエンマクロライドです。 ただし、ニスタチンやフィリピンと異なり、ピマリシンは原形質膜の透過性を変化させません。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC2803 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable