F6145

Fenspiride hydrochloride

analytical standard, for drug analysis

• 別名: 8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
• 実験式（ヒル表記法）: C₁₅H₂₀N₂O₂ · HCl
• CAS番号: 5053-08-7
• 分子量: 296.79
• EC Number: 225-752-9
• MDL番号: MFCD00133315
• UNSPSCコード: 41116107
• PubChem Substance ID: 329799751

特性

• グレード: analytical standard
• 品質水準: 200
• アッセイ: >99% (TLC)
• 形状: powder
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 色: white
• アプリケーション: forensics and toxicology; pharmaceutical (small molecule); veterinary
• フォーマット: neat
• SMILES記法: Cl.O=C1NCC2(CCN(CCc3ccccc3)CC2)O1
• InChI: 1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
• InChI Key: FIKFLLIUPUVONI-UHFFFAOYSA-N
• 遺伝子情報: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269)

詳細

アプリケーション

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

生物化学的／生理学的作用

Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H₁ histamine receptors.
Fenspiride hydrochloride possesses anti-allergic and anti-bronchoconstrictive properties. It is used as a drug to treat inflammatory conditions of the upper and lower respiratory tracts. Experimental studies state that fenspiride has an ability to reduce the development of myringosclerosis, possibly by restricting the formation of oxygen-derived free radicals.

抗炎症性の気管支拡張薬です。抗ムスカリン作用によって、接合部前のレベルで粘液分泌を阻害し、タキキニン放出を減少させます。本化合物は、αアドレナリン受容体やH₁ヒスタミン受容体のアンタゴニストでもあると考えられます。

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves