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品質水準
形状
powder
有効性
≥750 μg per mg (dry basis)
不純物
≤5% Kanamycin B
SMILES記法
OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI Key
OOYGSFOGFJDDHP-KMCOLRRFSA-N
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アプリケーション
Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 mg/mL.
生物化学的／生理学的作用
Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding.
Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.
Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
作用機序：この製品は、70Sリボソームサブユニットと結合し、転座を阻害し、ミスコーディングを誘発することで作用します。
耐性機序：アミノグリコシド修飾酵素（アセチルトランスフェラーゼ、ホスホトランスフェラーゼ、ヌクレオチジルトランスフェラーゼなど）は、この抗生物質を変化させることができ、リボソームとの相互作用を妨げます。
抗菌スペクトル：硫酸カナマイシンはグラム陰性およびグラム陽性細菌ならびにマイコプラズマに有効です。
耐性機序：アミノグリコシド修飾酵素（アセチルトランスフェラーゼ、ホスホトランスフェラーゼ、ヌクレオチジルトランスフェラーゼなど）は、この抗生物質を変化させることができ、リボソームとの相互作用を妨げます。
抗菌スペクトル：硫酸カナマイシンはグラム陰性およびグラム陽性細菌ならびにマイコプラズマに有効です。
注意
Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.
調製ノート
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Repr. 1B
保管分類コード
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
E004000-50G:
E004000-BULK:
E004000-5G:
E004000-VAR:
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