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グレード
analytical standard
品質水準
アッセイ
≥94.0% (GC)
シェルフライフ
limited shelf life, expiry date on the label
アプリケーション
clinical testing
フォーマット
neat
生物化学的／生理学的作用
2-Hydroxyadipic acid is a hydroxy-dicarboxylic acid formed by the reduction of 2-ketoadipic acid. Deficiency of 2-ketoadipic dehydrogenase causes 2-ketoadipic academia, a condition characterized by accumulation and excretion of 2-hydroxyadipic acid. A method involving derivatization and combined gas chromatography-mass spectrometry has been recently developed to separate the enantiomers of 3-hydroxyadipic acid. It has been shown that 3-hydroxyadipic acid excreted in urine consists of at least 95% of the L-enantiomer. This finding supports the hypothesis that dicarboxylic acids are degraded by ordinary beta-oxidation, and indicates that adipic acid may be converted into succinic acid.
アナリシスノート
may contain ethanol
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
H Przyrembel et al.
Clinica chimica acta; international journal of clinical chemistry, 58(3), 257-269 (1975-02-08)
Investigation of a psychomotorically retarded girl showed excretion of abnormal amounts of alpha-ketoadipic acid, alpha-hydroxyadipic acid, alpha-aminoadipic acid, 1,2-butenedicarboxylic acid and elevation of plasma alpha-aminoadipic acid levels. The identity of these metabolities was established by various methods. The excretion of
J S Svendsen et al.
Journal of chromatography, 337(1), 9-19 (1985-01-11)
A method involving derivatization and combined gas chromatography--mass spectrometry has been developed to separate the enantiomers of 3-hydroxyadipic acid. By combining this method with asymmetric synthesis of the same acid, it has been shown that 3-hydroxyadipic acid excreted in urine
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