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product name
IMG Mouse Microglial Cell Line, IMG microglial cells recapitulate key features of microglial cell activation and may be used to study neuroinflammatory responses underlying Alzheimer′s disease.
由来生物
mouse
品質水準
テクニック
cell based assay: suitable
輸送温度
ambient
関連するカテゴリー
詳細
Immortalized MicroGlial Cell Line or IMG is an immortalized microglial cell line derived from adult murine brain infected with the v-raf/v-myc retrovirus. IMG cells express markers that are specific to adult primary microglial cells (F4/80 and CD11b) as assessed by flow cytometry and are responsive to pro- and anti-inflammatory signals (1). They have been shown to phagocytose foreign particles and misfolded proteins such as the amyloid-beta peptide (1). IMG cells are rapidly dividing cells that are typically small and round with few or no processes when cultured in medium containing serum.
Reference:
1. McCarthy RC, Lu DY, Alkhateeb A, Gardeck AM, Lee CH and Wessling-Resnick M (2016). Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J. Neuroinflammation 13: 21
Reference:
1. McCarthy RC, Lu DY, Alkhateeb A, Gardeck AM, Lee CH and Wessling-Resnick M (2016). Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. J. Neuroinflammation 13: 21
Microglia are the primary immune cells of the central nervous system (CNS), and account for 10-15% of all cells found within the brain. Microglial cells play an important role in maintaining the health of the CNS by the removal of pathogens, infectious agents and damaged cells through phagocytosis. Microglial cells have also been extensively studied for their harmful roles in a variety of neurodegenerative disease including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis.
細胞株の説明
Macrophage Cells
アプリケーション
Research Category
免疫応答
炎症及び免疫
ニューロサイエンス
免疫応答
炎症及び免疫
ニューロサイエンス
Research Sub Category
神経変性疾患
神経炎症及び疼痛
神経変性疾患
神経炎症及び疼痛
This product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.
品質
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
保管および安定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
労働安全衛生法名称等を表示すべき危険物及び有害物
名称等を表示すべき危険物及び有害物
労働安全衛生法名称等を通知すべき危険物及び有害物
名称等を通知すべき危険物及び有害物
Jan Code
SCC134:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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