ABE798

Anti-KPNA6 Antibody

from rabbit, purified by affinity chromatography

• 別名: Importin subunit alpha-7, Karyopherin subunit alpha-6
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human
• テクニック: immunofluorescence: suitable; western blot: suitable
• UniProtアクセッション番号: O60684
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KPNA6(23633)

詳細

詳細

Importin subunit alpha-7, also known as Karyopherin subunit alpha-6, and encoded by the gene name KPNA6 or IPOA7, is a member of the Importin alpha family. KPNA6 is a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Randependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import

特異性

This antibody is predicted to not cross-react with other Importin alpha family members.

免疫原

KLH-conjugated synthetic peptide corresponding to the N-terminus of human KPNA6.

アプリケーション

Detect KPNA6 using this Anti-KPNA6 Antibody validated for use in western blotting & immunofluorescence.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected KPNA6 in HEK293 cells.

品質

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected KPNA6 in HEK293 cell lysate.

ターゲットの説明

~63 kDa observed. Uncharacterized bands may be observed in some lysate(s).

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable