Xenopus (based on 100% sequence homology), porcine (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
The protein named Ubiquitin carboxyl-terminal hydrolase 7, or Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, or Ubiquitin-specific-processing protease 7 and encoded by the human gene USP7/HAUSP is a ubiquitin specific hydrolase that deubiquitinates several key transcription factors and thus modulates their activity. Among the important factors are FOXO4, p53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, and DAXX. Thus USP7S is involved in cell proliferation and gene expression regulation and the regulation of the stress response pathways. Interestingly recent research has linked USP7S with regulating transcription-coupled nucleotide excision repair (TC-NER) and the being important in the disease of UV-sensitive syndrome (UVSS) too. USP7S is widely expressed and up regulated in many cancers including prostate cancer.
免疫原
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to a region near the N-terminus of human USP7S.
アプリケーション
Research Category アポトーシス及び癌
Research Sub Category アポトーシス-追加
Anti-USP7S Antibody detects level of USP7S & has been published & validated for use in USP7S.
Western Blotting Analysis: A 1:5,000 dilution of this antibody detected USP7S in HeLa whole cell extract (Dr. Grigory Dianov, University of Oxford, United Kingdom.)
品質
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected USP7S in 10 µg in HeLa cell lysate.
ターゲットの説明
~140 kDa observed
物理的形状
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
