AB15134

Anti-Neurotensin Receptor 2 Antibody

from rabbit, purified by affinity chromatography

• 別名: Levocabastine-sensitive neurotensin receptor, NTR2 receptor, neurotensin receptor 2, neurotensin receptor, type 2
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 交差性: human, mouse, rat
• テクニック: immunohistochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_036476
• UniProtアクセッション番号: O95665
• 輸送温度: wet ice
• 遺伝子情報: human ... NTSR2(23620)

詳細

詳細

Neurotensin Receptor 2 (NTR2) is a member of the G-protein coupled receptor family. Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents (Kinkead and Nemeroff, 2004). In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin (Castagliuolo et al., 1999). The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR2 recognizes a histamine H1 receptor antagonist that had been shown to compete with neurotensin for low-affinity binding sites in the brain.

特異性

This antibody recognizes Neurotensin Receptor 2.

免疫原

Epitope: Extracellular Domain

KLH-conjugated linear peptide from the extracellular domain of human Neurotensin Receptor 2.

アプリケーション

Research Category
ニューロサイエンス

代謝

Research Sub Category
神経伝達物質及び受容体

ホルモン及び受容体

Detect Neurotensin Receptor 2 using this Anti-Neurotensin Receptor 2 Antibody validated for use in WB, IH.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of mouse brain lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of rat brain lysate.

品質

Evaluated by Western Blot in human cortex lysate.

Western Blot Analysis: 1 µg/ml of this antibody detected Neurotensin Receptor 2 in 10 µg of human cortex lysate.

ターゲットの説明

45.413 kDa is the calculated molecular weight. In Western Blot, immunoreactive bands which might reflect multimeric species of Neurotensin Receptor 2, are detected at approximately 60-65 kDa, 75 kDa, and 80-85 kDa Sarret, P., et al. (2003). J Comp Neurol. 461(4):520-538.

関連事項

Replaces: AB9521

物理的形状

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Human cortex lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable