8.55061

HMPB-MBHA resin

Novabiochem^®

• 別名: 4-Hydroxymethyl-3-methoxyphenoxybutyric acid MBHA resin
• UNSPSCコード: 13111023
• NACRES: NA.22

特性

• 品質水準: 200
• 製品種目: Novabiochem^®
• フォーム: beads
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• メーカー／製品名: Novabiochem^®
• アプリケーション: peptide synthesis
• 官能基: alcohol
• 保管温度: 2-30°C

詳細

詳細

This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker ^[1].This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments. Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoylchloride/pyridine ^[2] or MSNT/Melm activation ^[3,4,5].Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

関連事項

Replaces: 01-64-0036

アナリシスノート

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

法的情報

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable