654380

Tunicamycin

from Strepomyces lysosuperficus, ≥98% (A+B+C+D, HPLC), powder, N-acetylglucosamine transferase, Calbiochem

• 別名: Tunicamycin, Streptomyces lysosuperficus
• 実験式（ヒル表記法）: C₃₉H₆₄N₄O₁₆
• CAS番号: 11089-65-9
• 分子量: 844.94
• MDL番号: MFCD00065709
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Tunicamycin, Streptomyces lysosuperficus,
• 詳細: Tunicamycin, Streptomyces lysosuperficus
• 品質水準: 200
• アッセイ: ≥98% (A+B+C+D, HPLC)
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 溶解性: DMSO: 10 mg/mL; DMF: soluble; pyridine: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1
• InChI Key: ZHSGGJXRNHWHRS-PEALBESXSA-N

詳細

詳細

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells.

生物化学的／生理学的作用

Primary Target
N-linked glycosylation

Secondary Target
thrombin-induced Ca²⁺ mobilization in cells

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

調製ノート

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

再構成

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 1 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable