565761

γ-Secretase Inhibitor IV

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
• 実験式（ヒル表記法）: C₂₅H₂₆N₂O₃
• 分子量: 402.49
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβ_x-40 (ED₅₀ = 2.6 µM) and Aβ_x-42 (ED₅₀ = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.

生物化学的／生理学的作用

Cell permeable: yes

ED50 = 2.6 µM for Aβx-40

Primary Target
Aβ_x-40

Product does not compete with ATP.

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

2-Naphthoyl-Val-Phe-CHO

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable