565750

γ-Secretase Inhibitor I

The γ-Secretase Inhibitor I controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: γ-Secretase Inhibitor I, Z-LLNle-CHO
• 実験式（ヒル表記法）: C₂₆H₄₁N₃O₅
• 分子量: 475.62
• UNSPSCコード: 12352200
• NACRES: NA.54

特性

• 品質水準: 200
• アッセイ: ≥90% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: DMSO: 10 mg/mL; 50% acetic acid: soluble
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Cell permeable. Inhibits γ-secretase, a protease that cleaves the Amyloid Precursor Protein (APP) to generate β-amyloid protein. Inhibition of this enzyme is believed to aid in the prevention of Alzheimer’s disease.

Inhibits γ-secretase, a protease that cleaves the amyloid precursor protein (APP). Inhibition of this enzyme is believed to aid in the prevention of Alzheimer′s disease.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Leu-Leu-Nle-CHO (Nle = Norleucine)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Skovronsky, D.M., et al. 2000. Biochemistry 39, 810.
Hartmann, T., et al. 1997. Nat. Med. 3, 1016.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable