553512

Rac1 Inhibitor II, Z62954982

InSolution, ≥93%

• 別名: InSolution Rac1 Inhibitor II, Z62954982, Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide
• 実験式（ヒル表記法）: C₂₀H₂₁N₃O₅S
• CAS番号: 1090893-12-1
• 分子量: 415.46
• MDL番号: MFCD11736677
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥93% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CC1=CC=C(NC(C2=CC(OCC3=C(C)ON=C3C)=CC=C2)=O)C=C1S(N)(=O)=O
• InChI: 1S/C20H21N3O5S/c1-12-7-8-16(10-19(12)29(21,25)26)22-20(24)15-5-4-6-17(9-15)27-11-18-13(2)23-28-14(18)3/h4-10H,11H2,1-3H3,(H,22,24)(H2,21,25,26)
• InChI Key: OZZQJOAJXMUXCO-UHFFFAOYSA-N

詳細

詳細

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511" target="_blank">553511) is also available.

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO

再構成

Following initial thaw, aliquot and freeze (-20°C).

その他情報

Ferri, N., et al. 2009. J. Med. Chem.52, 4087.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 188.6 °F - closed cup - (refers to pure substance)
• 引火点(℃): 87 °C - closed cup - (refers to pure substance)