5.33796

Asparagine Endopeptidase Inhibitor, AENK

• 別名: Asparagine Endopeptidase Inhibitor, AENK, Fmoc-Ala-Glu-Asn-Lys-NH2, Asparagine Endopeptidase Inhibitor, AENK, AEP Inhibitor, AENK
• 実験式（ヒル表記法）: C₃₃H₄₃N₇O₉
• 分子量: 681.74
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 25 mg/mL
• 保管温度: −20°C

詳細

詳細

An amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

An amino and carboxy-terminal blocked tetra peptide that acts as a specific, competitive inhibitor of the protease activity of asparagine endopeptidase (AEP), an enzyme that cleaves substrates on the C-terminal side of asparagine. Believed to act as a competitive substrate that itself is hydrolyzed by AEP. Shown to block processing of tetanus toxin antigen (TTCF) in vitro (~1 mg/ml) and retard TTCF presentation to T cells in vivo. Does not affect the cleavage of cathepsin B/L and cathepsin S substrates. Shown to selectively and completely suppress tau cleavage by AEP (~ 1 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

生物化学的／生理学的作用

Primary Target
AEP

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Fmoc-Ala-Glu-Asn-Lys-NH2

物理的形状

Supplied as a TFA salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Zhang, Z., et al. 1999. Nat. Med.20, 1254.
Monoury, B., et al. 1998. Nat.396, 695.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable