5.08505

A-803467

• 別名: A-803467, Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
• 実験式（ヒル表記法）: C₁₉H₁₆ClNO₄
• CAS番号: 944261-79-4
• 分子量: 357.79
• MDL番号: MFCD10574689
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 8 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mM; ethanol: 25 mM
• 保管温度: 2-8°C
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChI Key: VHKBTPQDHDSBSP-UHFFFAOYSA-N

詳細

詳細

A voltage gated sodium channel type 1.8 (Na_v1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC₅₀) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Na_v1.8 (IC₅₀ = 8 nM) and was >100-fold selective vs. human Na_v1.2, Na_v1.3, Na_v1.5, and Na_v1.7 (IC₅₀ values ≥ 1 µM).

生物化学的／生理学的作用

Primary Target
Na_v1.8

警告

Toxicity: Standard Handling (A)

その他情報

Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable