5.04905

Memantine Hydrochloride

• 別名: Memantine Hydrochloride, 3,5-Dimethyl-1-adamantanamine hydrochloride
• 実験式（ヒル表記法）: C₁₂H₂₁N · xHCl
• CAS番号: 41100-52-1
• 分子量: 179.30 (free base basis)
• MDL番号: MFCD00214336
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: H₂O: 100 mM
• 保管温度: 2-8°C
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
• InChI Key: LDDHMLJTFXJGPI-UHFFFAOYSA-N

詳細

詳細

A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC₅₀ = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).

Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.

生物化学的／生理学的作用

Primary Target
NMDA receptors

Target IC₅₀: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.
Anand, A., et al. 2012. Bipolar Dis.14, 64.
Lopes, P., et al. 2013. Brain and Behavior.3, 67.
Howard, R., et al. 2012. New Eng. J. Med.366, 893.
Parsons, G., et al. 1999. Neuropharmacol.38, 735.
Lee, G., et al. 2012. Psychiatry Investig.9, 166.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable