5.04844

7-Chlorokynurenic Acid Sodium Salt

• 別名: 7-Chlorokynurenic Acid Sodium Salt, 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
• 実験式（ヒル表記法）: C₁₀H₅ClNNaO₃
• CAS番号: 1263094-00-3
• 分子量: 245.59
• UNSPSCコード: 12352106
• NACRES: NA.77

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: solid
• 有効性: 0.56 μM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 100 mM
• 保管温度: 2-8°C
• InChI: 1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1
• InChI Key: IFZYIORLNGNLEI-UHFFFAOYSA-M

詳細

詳細

A very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC₅₀ = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.

生物化学的／生理学的作用

Primary Target
NMDA receptors

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Kemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A.85, 6550.
Kretschmer, D., et al. 1995. Eur. J. Pharmacol.280, 37.
Bartlett, D., et al. 1999. Neuropharmacol.37, 839.
Moroni, F., et al. 1991. Eur. J. Pharmacol.199, 32.
Stone, W., et al. 2012. FEBS J.279, 1386.
Vécsei, L., et al. 2012. Nat. Rev. Drug Disc.12, 64.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable