475895

Monensin, Sodium Salt, High Purity

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane.

• 別名: Monensin, Sodium Salt, High Purity
• 実験式（ヒル表記法）: C₃₆H₆₁O₁₁ · Na
• CAS番号: 22373-78-0
• 分子量: 692.85
• MDL番号: MFCD00077826
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥97% (by Assay)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: off-white to beige
• 溶解性: chloroform: soluble; ethanol: soluble; methanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-;/m0./s1
• InChI Key: XOIQMTLWECTKJL-FBZUZRIGSA-M

詳細

詳細

Polyether antibiotic that functions as a Na⁺ ionophore by forming stable complexes with monovalent cations that are able to cross the plasma membrane. Blocks glycoprotein secretion. Inhibits the ability of HDL to decrease cellular cholesterol esterification. Also reported to induce catecholamine secretion from adrenal chromaffin cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Functions as a Na+ ionophore

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Highly Toxic (H)

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Unstable in acidic solutions.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Inabayashi, M., et al. 1995. Biochemistry34, 3455.
Mendez, A.J. 1995. J. Biol. Chem.270, 5891.
Sakuragawa, N., et al. 1994. Biochim. Biophys. Acta1213, 193.
Griffin, T., et al. 1993. J. Natl. Cancer Inst.85, 292.
Rushfeldt, C., and Smedsrtod, B. 1993. Cancer Res.53, 658.
Hoya, A., and Venosa, R.A. 1992. Biochem. Biophys. Acta1104, 123.
Kok, J.W. 1992. J. Cell. Sci.103, 1139.
Takemura, H., and Ohshika, H. 1992. Biochem. Pharmacol.44, 1395.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H300,H319,H373,H411
• 注意書き: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• 危険有害性の分類: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• ターゲットの組織: Heart,muscle
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable