472804

S-Methyl-L-thiocitrulline, Dihydrochloride

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

• 別名: S-Methyl-L-thiocitrulline, Dihydrochloride, N ^δ-(S-Methyl)isothioureido-L-ornithine, N^δ-(S-Methyl)isothioureido-L-ornithine
• 実験式（ヒル表記法）: C₇H₁₅N₃O₂S · 2HCl
• CAS番号: 209589-59-3
• 分子量: 278.20
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white to off-white
• 溶解性: water: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C7H15N3O2S/c1-13-7(9)10-4-2-3-5(8)6(11)12/h5H,2-4,8H2,1H3,(H2,9,10)(H,11,12)/t5-/m0/s1
• InChI Key: NGVMVBQRKZPFLB-YFKPBYRVSA-N

詳細

詳細

A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

A cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC₅₀ = 300 nM) compared to the endothelial enzyme (IC₅₀ = 5.4 µM).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Rat neuronal nitric oxide synthase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM for rat neuronal nitric oxide synthase

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Krishnaswamy, N., et al. 1995. J. Biol. Chem.270, 11103.
Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem.37, 885.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3