407241

Insulin Degrading Enzyme, His•Tag^®, Rat, Recombinant, S. frugiperda

• 別名: Insulysin, IDE
• Enzyme Commission number: 3.4.24.56 (BRENDA, IUBMB)
• UNSPSCコード: 12352202
• NACRES: NA.25

特性

• アッセイ: ≥90% (SDS-PAGE)
• 品質水準: 100
• 形状: liquid
• 比活性: ≥3 units/mg protein
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 輸送温度: wet ice
• 保管温度: −70°C

詳細

詳細

Recombinant, rat insulin degrading enzyme fused to a His•Tag sequence and expressed in S. frugiperda insect cells. A metalloprotease that degrades insulin and a variety of other peptides including amyloid peptides.

Recombinant, rat insulin degrading enzyme fused to a His•Tag sequence and expressed in S. frugiperda insect cells. Insulin degrading enzyme (Insulysin) is a metalloprotease that degrades insulin and a variety of other peptides, including glucagon, insulin-like growth factors I and II, atrial natriuretic peptide, TGF-α, and amyloid peptides. Reported to be inversely correlated with brain Aβ peptide levels in insulysin-deficient mice compared to wild-type mice.

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

単位の定義

One unit is defined as the amount of the enzyme that will catalyze the hydrolysis of 1 µmol iodinated insulin per h at 37°C, pH 7.3.

物理的形状

In 100 mM potassium phosphate buffer, 20% glycerol, pH 7.3.

再構成

Following initial thaw, aliquot and freeze (-70°C).

その他情報

Hersh, L.B. 2003. Curr. Pharm. Des.9, 449.
Miller, B.C., et al. 2003. Proc. Natl. Acad. Sci. USA100, 6221.
Song, E.S., et al. 2003. J. Biol. Chem.278, 49789.
Mukherjee, A., and Hersh, L.B. 2002. J. Alzheimer′s Dis.4, 341.
Song, E.S., et al. 2001. J. Biol. Chem.276, 1152.
Becker, A.B., and Roth, R.A. 1995. Methods Enzymol.248, 693.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1