217694

Cdc25 Inhibitor IV, NSC 95397

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Cdc25 Inhibitor IV, NSC 95397, (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
• 実験式（ヒル表記法）: C₁₄H₁₄O₄S₂
• CAS番号: 93718-83-3
• 分子量: 310.39
• MDL番号: MFCD04040032
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange
• 溶解性: DMSO: 100 mg/mL, clear, red
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: O=C1C(SCCO)=C(SCCO)C(C2=CC=CC=C21)=O
• InChI: 1S/C14H14O4S2/c15-5-7-19-13-11(17)9-3-1-2-4-10(9)12(18)14(13)20-8-6-16/h1-4,15-16H,5-8H2
• InChI Key: MAASHDQFQDDECQ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (K_i = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G₂M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC₅₀ = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Dulyaninova, N.G., et al. 2011. Biochemistry50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol.61, 720.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable