203995

N-tert-Butyl-α-phenylnitrone

Most commonly-used free radical trap.

• 別名: N-tert-Butyl-α-phenylnitrone, PBN
• 実験式（ヒル表記法）: C₁₁H₁₅NO
• CAS番号: 3376-24-7
• 分子量: 177.24
• MDL番号: MFCD00008799
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (GC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 10 mg/mL; water: 20 mg/mL; chloroform: 50 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3
• InChI Key: IYSYLWYGCWTJSG-UHFFFAOYSA-N

詳細

詳細

Most commonly used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative diseases. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Most commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Free radical trap

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution in DMSO aliquot and freeze (-20°C). Stock solutions in DMSO are stable for up to 2 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.

その他情報

Floyd, R.A. 1997. Adv. Pharmacol. 38, 361.
Miyajima, T., and Kotake, Y. 1995. Biochem. Biophys. Res. Commun. 215, 114.
Jazen, E.G., et al. 1994. in Frontiers of Reactive Oxygen Species in Biology and Medicine, (Asada, K., and Yoshikawa, T., eds.), pp. 431-434. Elsevier Science, Amsterdam.
Floyd, R.A. 1990. FASEB J. 4, 2587.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable