14-923-M

Flt1 Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant, human Flt1, amino acids 783-end. For use in Kinase Assays.

• UNSPSCコード: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: human
• 品質水準: 100; 300
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 89 kDa
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• GenBankアクセッション番号: AF063657
• UniProtアクセッション番号: P17948

詳細

詳細

Product Source: N-terminal GST-tagged, recombinant, human Flt1 amino acids 783-end, expressed by baculovirus in Sf21 insect cells.

This protein encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

アプリケーション

Research Category
細胞シグナル伝達

生物化学的／生理学的作用

Protein Target: Flt1

Target Sub-Family: TK

包装

Also available in 250μg size as catalog # 14-923M and in bulk as catalog # 14-923-K.

品質

Routinely evaluated by phosphorylation of peptide KKKSPGEYVNIEFG

物理的形状

Purified using glutathione sepharose.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

GenBank is a registered trademark of United States Department of Health and Human Services

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable