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Merck
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資料

安全性情報

07-724

Sigma-Aldrich

Anti-α-Insulin Receptor Antibody, β subunit

Upstate®, from rabbit

別名:

CD220 antigen, insulin receptor

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About This Item

UNSPSCコード:
12352203
eCl@ss:
32160702
NACRES:
NA.41

由来生物

rabbit

品質水準

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

精製方法

affinity chromatography

化学種の反応性

mouse, human, rat

化学種の反応性(ホモロジーによる予測)

chimpanzee

メーカー/製品名

Upstate®

テクニック

immunoprecipitation (IP): suitable
western blot: suitable

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... INSR(3643)

詳細

The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.

特異性

This antibody recognizes α-Insulin Receptor, β subunit.

免疫原

Epitope: C-terminus
GST-fusion protein corresponding to the last 100 C-terminal amino acid residues of the human insulin receptor β chain

アプリケーション

Research Category
細胞シグナル伝達

代謝
Research Sub Category
インスリン/エネルギーシグナル伝達
Anti-α-Insulin Receptor Antibody, β subunit is an antibody against a-Insulin Receptor for use in IP & WB.
Immunoprecipitation Analysis:

品質

Evaluated by Western Blot in Human brain tissue lysate.
Western Blot Analysis: : 1:1,000 dilution of this antibody detected α-Insulin Receptor, β subunit in human brain tissue lysate.

ターゲットの説明

97 kDa

物理的形状

Affinity purified
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide.

保管および安定性

Maintain refrigerated at 2-8°C for for 1 year from date of receipt.

アナリシスノート

Control
Human brain tissue lysate

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 1


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

07-724:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Makoto Takahashi et al.
Oncology reports, 37(5), 2929-2941 (2017-04-11)
We investigated the relationship among serum insulin level, insulin receptor (IR) expression in renal cell carcinoma (RCC), and outcomes in patients with RCC who underwent nephrectomy. We also explored the role of insulin signaling in RCC progression in a murine RCC
Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKK?/? phosphorylation are increased in obese Zucker rat skeletal muscle.
Zolotnik, IA; Figueroa, TY; Yaspelkis, BB
Life Sciences null
Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle.
Ben B Yaspelkis,Ilya A Kvasha,Sarah J Lessard,Donato A Rivas,John A Hawley
European Journal of Applied Physiology null
Insulin responsiveness in metabolic syndrome after eight weeks of cycle training.
Stuart, CA; South, MA; Lee, ML; McCurry, MP; Howell, ME; Ramsey, MW; Stone, MH
Med Sci Sports Exerc. null
Michael E Cox et al.
The Prostate, 69(1), 33-40 (2008-09-12)
Although recent laboratory and population studies suggest that prostate cancer may be responsive to insulin, there is a gap in knowledge concerning the expression of insulin receptors on benign or malignant prostate tissue. We immunostained 644 cores on tissue microarrays

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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