07-2045
Anti-EHMT1 Antibody (CT)
from rabbit
別名:
G9a like protein, G9a-like protein 1, H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5, Lysine N-methyltransferase 1D, euchromatic histone methyltransferase 1, euchromatic histone-lysine N-methyltransferase 1
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About This Item
UNSPSCコード:
12352203
eCl@ss:
32160702
おすすめの製品
由来生物
rabbit
抗体製品タイプ
primary antibodies
クローン
polyclonal
交差性
human
テクニック
ELISA: suitable
immunocytochemistry: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... EHMT1(79813)
詳細
EHMT1 (euchromatic histone methyltransferase 1), also known as G9a-like protein (GLP1), is a histone methyltransferase. This protein specifically methylates Lysine 9 of histone H3 in vitro. H3Lys9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is thought to be targeted to histone H3 by different DNA-binding proteins including E2F6, MGA, MAX and/or DP1. During G0 phase, it contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle. EMHT1/GLP1 is phosphorylated upon DNA damage, probably by ATM or ATR. Defects in EHMT1 result in severe mental retardation, hypotonia, and epileptic seizures.
特異性
Not tested in other species.
免疫原
Epitope: C-terminus
The immunogen was a KLH-conjugated synthetic peptide corresponding the C-terminal region of human EHMT1.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
ヒストン修飾タンパク質
エピジェネティクス
ヒストン修飾タンパク質
エピジェネティクス
Anti-EHMT1 (C-terminus) Antibody is a Rabbit Polyclonal Antibody for detection of EHMT1 also known as H3-K9-HMTase 5, Histone H3-K9 methyltransferase 5 & has been validated in ICC, ELISA & WB.
Western Blot Analysis:
This antibody is reported by an outside laboratory to be suitable for Western blotting using EHMT1-transfected 293 cells.
ELISA:
This antibody is reported by an outside laboratory to be suitable for ELISA.
This antibody is reported by an outside laboratory to be suitable for Western blotting using EHMT1-transfected 293 cells.
ELISA:
This antibody is reported by an outside laboratory to be suitable for ELISA.
品質
Immunocytochemistry:
The antibody detects EHMT1 in HeLa cell nuclei.
The antibody detects EHMT1 in HeLa cell nuclei.
ターゲットの説明
~138 kDa
物理的形状
Protein A chromatography
Format: Purified
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
アナリシスノート
Control
HeLa cells
HeLa cells
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
07-2045:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
T Nagase et al.
DNA research : an international journal for rapid publication of reports on genes and genomes, 8(2), 85-95 (2001-05-12)
To accumulate information on the coding sequences of unidentified genes, we have carried out a sequencing project of human cDNA clones which encode large proteins. We herein present the entire sequences of 100 cDNA clones of unidentified human genes, named
Hidesato Ogawa et al.
Science (New York, N.Y.), 296(5570), 1132-1136 (2002-05-11)
E2F-6 contributes to gene silencing in a manner independent of retinoblastoma protein family members. To better elucidate the molecular mechanism of repression by E2F-6, we have purified the factor from cultured cells. E2F-6 is found in a multimeric protein complex
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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