07-1386

Anti-Connective Tissue Growth Factor Antibody

from goat

• 別名: Hypertrophic chondrocyte-specific protein 24, connective tissue growth factor, insulin-like growth factor-binding protein 8
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: goat
• 品質水準: 100
• 抗体製品の状態: purified antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• テクニック: western blot: suitable
• NCBIアクセッション番号: NP_001892.1
• UniProtアクセッション番号: P29279
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CTGF(1490)

詳細

詳細

Connective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells.

特異性

Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology).

This antibody recognizes the mature chain of Connective tissue growth factor.

免疫原

Epitope: Mature chain

Recombinant protein corresponding to the mature chain of human Connective tissue growth factor.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
成長因子及び受容体

Anti-Connective Tissue Growth Factor Antibody detects level of Connective Tissue Growth Factor & has been published & validated for use in WB.

品質

Evaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates.

Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates.

ターゲットの説明

In Western Blot, full length CTGF is observed at 38 kDa and CTGF N&C domain is observed at 19 kDa

物理的形状

Protein G Purified

Format: Purified

Purified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

アナリシスノート

Control
Untreated and TGFb1 treated NRK cell lysates

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable