B-054

Buspirone hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₂₁H₃₁N₅O₂ · HCl
• CAS番号: 33386-08-2
• 分子量: 421.96
• MDL番号: MFCD00078569
• UNSPSCコード: 41116107
• PubChem Substance ID: 329773117
• NACRES: NA.24

特性

• グレード: certified reference material
• 形状: liquid
• 特徴: (Snap-N-Spike^®)
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: clinical testing
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: O=C1CC2(CCCC2)CC(N1CCCCN(CC3)CCN3C4=NC=CC=N4)=O.Cl
• InChI: 1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
• InChI Key: RICLFGYGYQXUFH-UHFFFAOYSA-N
• 遺伝子情報: human ... HTR1A(3350)

詳細

詳細

Buspirone, sold under the trade name Buspar^®, is an antidepressant marketed for treatment of generalized anxiety disorder and clinical depression. Suitable uses for this Certified Spiking Solution^®include as starting material for calibrators and controls in antidepressant testing methods by LC/MS or GC/MS for clinical toxicology, urine drug testing, or forensic analysis applications.

アプリケーション

• Optimization of Buspirone Hydrochloride-Loaded In Situ Gel for Pediatric Anxiety: This study utilized response surface methodology to develop an optimized formulation of buspirone hydrochloride in situ gel, specifically designed for pediatric anxiety treatment. (Abdallah et al., 2022).


• Behavioral Effects of Buspirone in Juvenile Zebrafish: Investigating the behavioral effects of buspirone on juvenile zebrafish of two different genetic backgrounds, this study highlights the potential of buspirone hydrochloride solution to serve as a critical tool in neuropharmacological research, especially in studying anxiolytic compounds and their mechanisms of action within the GABAergic system (Abozaid et al., 2022).


• Nasal Delivery System for Buspirone Hydrochloride: Focused on the development of buspirone hydrochloride-loaded nanovesicular gels for nasal delivery, this research explores an innovative approach to administering psychiatric medication, providing a promising alternative to traditional oral routes. This method could potentially enhance the bioavailability and onset of action of buspirone, making it more effective for treating anxiety disorders (Abdelnabi et al., 2019).

法的情報

Buspar is a registered trademark of Bristol-Myers Squibb Co.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup