857393P

THI

2-acetyl-5-tetrahydroxybutyl imidazole, powder

• 別名: 2-acetyl-4-tetrahydroxybutyl imidazole; 2-acetyl-4(5)-tetrahydroxybutyl imidazole; 2-ATHBI
• 実験式（ヒル表記法）: C₉H₁₄N₂O₅
• CAS番号: 94944-70-4
• 分子量: 230.22
• MDL番号: MFCD18427707
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >98% (TLC)
• フォーム: powder
• 包装: pkg of 1 × 1 mg (857393P-1mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 857393P
• 脂質タイプ: sphingolipids; bioactive lipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: [nH]1c(ncc1[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)C
• InChI: 1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
• InChI Key: CQSIXFHVGKMLGQ-BWZBUEFSSA-N

詳細

詳細

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate lyase (S1P lyase).[1]

Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. 2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of S1P lyase.[2] Because S1P lyase is primarily expressed in lymphatic tissue, treatment of mice with THI (50 μg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs.[2][3] The resulting lymphopenia is reversible following cessation of THI treatment.[4] Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists.[5]

生物化学的／生理学的作用

2-Acetyl-5-tetrahydroxybutyl imidazole (THI) can block S1P lyase in vivo and up-regulates circulatory and tissue S1P levels.[6] It has the ability to repress dystrophic muscle degeneration.[7]

包装

5 mL Amber Glass Screw Cap Vial (857393P-1mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable