857371P

VU0359595

(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder

• 別名: EVJ; VU0359595
• 実験式（ヒル表記法）: C₂₅H₂₉BrN₄O₂
• CAS番号: 1246303-14-9
• 分子量: 497.43
• MDL番号: MFCD22416858
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• フォーム: powder
• 包装: pkg of 1 × 1 mg (857371P-1mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 857371P
• 脂質タイプ: bioactive lipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: Brc1cc2[nH][c]([n](c2cc1)C3CCN(CC3)C[C@@H](NC(=O)[C@H]4[C@@H](C4)c5ccccc5)C)=O
• InChI Key: JSVNNLRZCJAYTQ-ORYQWCPZSA-N

詳細

詳細

VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder

アプリケーション

VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis[1] and as PLD1 inhibitor to treat the knockout mice to study its effects on them.[2]

生物化学的／生理学的作用

VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.[3]

包装

5 mL Amber Glass Screw Cap Vial (857371P-1mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable