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![VU0359595 (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder](/deepweb/assets/sigmaaldrich/product/structures/317/424/cb93743d-b88f-4f55-8826-293f2730f20f/640/cb93743d-b88f-4f55-8826-293f2730f20f.png)
アッセイ
>99% (TLC)
形状
powder
包装
pkg of 1 × 1 mg (857370P-1mg)
メーカー／製品名
Avanti Research™ - A Croda Brand 857370P
脂質タイプ
bioactive lipids
輸送温度
dry ice
保管温度
−20°C
アプリケーション
VU0155056 has been used as a phospholipase D-1 (PLD1) inhibitor:
- to study its role in regulated exocytosis
- to test bacterial and human PLD enzymes for specificity of inhibition
- in neuro-2a (N2a) cell culture and survival assay
生物化学的／生理学的作用
VU0155056 or N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl ethyl)-2-naphthamide is a cell permeable phospholipase D (PLD) inhibitor. It inhibits both PLD1 and PLD2.
包装
5 mL Amber Glass Screw Cap Vial (857370P-1mg)
法的情報
Avanti Research is a trademark of Avanti Polar Lipids, LLC
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
857370P-VAR:
857370P-1MG:
857370P-BULK:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Aditya Kulkarni et al.
Chemical biology & drug design, 84(3), 270-281 (2014-03-20)
Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based
Michael A Kennedy et al.
PLoS genetics, 7(2), e1001299-e1001299 (2011-02-25)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates
Sarah McDavid et al.
PloS one, 9(10), e109203-e109203 (2014-10-03)
Butanol (C4H10OH) has been used both to dissect the molecular targets of alcohols/general anesthetics and to implicate phospholipase D (PLD) signaling in a variety of cellular functions including neurotransmitter and hormone exocytosis. Like other primary alcohols, 1-butanol is a substrate
Sarah A Scott et al.
Nature chemical biology, 5(2), 108-117 (2009-01-13)
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitors
Tatiana P Rogasevskaia et al.
The Journal of biological chemistry, 290(48), 28683-28696 (2015-10-04)
There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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