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詳細
cholest-5-ene-3β,22(S)-diol-d7
アッセイ
>99% (TLC)
フォーム
powder
包装
pkg of 1 × 1 mg (700051P-1mg)
メーカー／製品名
Avanti Research™ - A Croda Brand
輸送温度
dry ice
保管温度
−20°C
詳細
22(S)-hydroxycholesterol is an enantiomer of 22(R)-hydroxycholesterol.[1] 22(S)-hydroxycholesterol-d7 is a deuterated form of 22(S)-hydroxycholesterol.
アプリケーション
22(S)-hydroxycholesterol-d7 may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma low-density lipoprotein (LDL).[2]
生物化学的／生理学的作用
22(S)-hydroxycholesterol (22(S)-HC) promotes glucose catabolism and uptake and is regarded as a potential target to treat type 2 diabetes.[3] 22(S)-HC also prevents the accumulation of lipids and lipid synthesis in hepatocytes and myotubes.[3] Unlike 22(R)-hydroxycholesterol, 22(S)-HC is not estrogenic and is not a ligand for liver X receptor (LXR).[1]
包装
5 mL Amber Glass Screw Cap Vial (700051P-1mg)
法的情報
Avanti Research is a trademark of Avanti Polar Lipids, LLC
保管分類コード
11 - Combustible Solids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
700051P-VAR:
700051P-BULK:
700051P-1MG:
最新バージョンのいずれかを選択してください：
Hiroyoshi Sato et al.
Bioscience, biotechnology, and biochemistry, 68(8), 1790-1793 (2004-08-24)
In order to test the estrogenic activity of sterol oxidation products from cholesterol and phytosterols, an estrogen-dependent gene expression assay was performed in estrogen receptor alpha-stably transformed HeLa cells. The ranking of the estrogenic potency of these compounds was different:
Nina Pettersen Hessvik et al.
The Journal of steroid biochemistry and molecular biology, 128(3-5), 154-164 (2011-11-05)
The aim of this study was to explore the effects of 22(S)-hydroxycholesterol (22(S)-HC) on lipid and glucose metabolism in human-derived cells from metabolic active tissues. Docking of T0901317 and 22(S)-HC showed that both substances fitted into the ligand binding domain
Myung-Jin Oh et al.
Journal of lipid research, 57(5), 791-808 (2016-03-19)
Endothelial biomechanics is emerging as a key factor in endothelial function. Here, we address the mechanisms of endothelial stiffening induced by oxidized LDL (oxLDL) and investigate the role of oxLDL in lumen formation. We show that oxLDL-induced endothelial stiffening is
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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