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アッセイ
99%
形状
powder
mp
183-185 °C (lit.)
SMILES記法
O=C1NN=Cc2ccccc12
InChI
1S/C8H6N2O/c11-8-7-4-2-1-3-6(7)5-9-10-8/h1-5H,(H,10,11)
InChI Key
IJAPPYDYQCXOEF-UHFFFAOYSA-N
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適用法令
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Jan Code
P39001-500G:
P39001-VAR:
P39001-100G:
P39001-BULK:
P39001-5G:
試験成績書（COA）
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Craig Zetterberg et al.
Drug metabolism and disposition: the biological fate of chemicals, 44(8), 1286-1295 (2016-06-15)
(R)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide (VX-509, decernotinib) is an oral Janus kinase 3 inhibitor that has been studied in patients with rheumatoid arthritis. Patients with rheumatoid arthritis often receive multiple medications, such as statins and steroids, to manage the signs and symptoms of comorbidities
Raghava Choudary Palacharla et al.
Xenobiotica; the fate of foreign compounds in biological systems, 49(2), 169-176 (2018-02-01)
The objective is to evaluate methoxsalen as an in vitro phenotyping tool in comparison to ABT as a nonspecific inactivator of P450 mediated metabolism. The reversible inhibition of methoxsalen and ABT against the P450, FMO, AO, MAO-A and -B, enzymes
Shengyun Huang et al.
Journal of separation science, 43(17), 3565-3572 (2020-07-07)
Capillary electrophoresis is a modern separation technique characterized by many benefits, which qualify it also for enzyme assays and the study of enzyme kinetics during drug development. Homogeneous or heterogeneous approaches can be followed for the enzymatic incubation. In this
Yasuhiro Uno et al.
Xenobiotica; the fate of foreign compounds in biological systems, 51(4), 494-499 (2021-01-13)
The cynomolgus macaque is a non-human primate species widely used in drug metabolism studies. Despite the importance of genetic polymorphisms in cytosolic aldehyde oxidase (AOX) 1 in humans, genetic variants have not been investigated in cynomolgus or rhesus macaques.Genetic variants
Takayuki Amano et al.
Biochemical pharmacology, 151, 69-78 (2018-03-10)
Dantrolene is used for malignant hyperthermia during anesthesia, and it sometimes causes severe liver injury as a side effect. Dantrolene is metabolized to acetylaminodantrolene, which is formed via the reduction of dantrolene to aminodantrolene and subsequent acetylation. Formation of hydroxylamine
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