923338

5-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)pyrazine-2-carboxylic acid

• 別名: Rigid linker for PROTAC^® development
• 実験式（ヒル表記法）: C₁₆H₂₁N₃O₅
• 分子量: 335.36
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• 形状: powder or crystals
• 品質水準: 100
• 反応適合性: reagent type: linker
• 官能基: Boc; carboxylic acid
• 保管温度: 2-8°C
• SMILES記法: OC(C1=NC=C(OC2CC3(C2)CN(C(OC(C)(C)C)=O)C3)N=C1)=O

詳細

アプリケーション

5-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
923311
923370
923419
923346
923427

その他情報

Crosslinkers

Protein Degrader Building Blocks

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight:Degrader Building Blocks for Targeted Protein Degradation

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable