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Microfludic device kit for synthesizing nanparticles
Kit components :
品質水準
アプリケーション
advanced drug delivery
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詳細
NanoFabTx™ Microfluidic - nano device kit is a set of plug-and-play, easy-to-use microfluidic components that are compatible with Dolomite microfluidic systems and standard syringe pumps (not included). The device kit can be combined with our special nanoformulation kits (please visit www.sigmaaldrich.com/nanofabtx) to form nanoparticles or liposomes 100 to 200 nm in size. The device kit includes a comprehensive protocol, pre-assembled microfluidic chip manifold, tubing, and required accessories.
アプリケーション
NanoFabTx™ Microfluidic - nano device kit is designed to work with NanoFabTx™ - nano reagent kits (including 909637, 918075, and 907766) to synthesize drug-encapsulating liposome nanoparticles (LNP) and drug-encapsulating polymeric nanoparticles for targeted drug delivery research. Our device kit simplifies LNP formulation and polymeric nanoformulation by leveraging microfluidic technologies to achieve narrow size dispersity and high batch-to-batch consistency. The microfluidic chip manifold is chemically robust and compatible with a variety of solvents and therapeutics relevant in nanomedicine. The microfluidic chip geometries and controllable flow enable the user to achieve targetable particle diameters with homogenous shape and structure from 100 to 200 nm in size. By enabling users to easily fine-tune the synthetic parameters, our microfluidic-based tool allows scalable synthesis of drug-encapsulating nanocarriers for researchers in the field of precision medicine, drug discovery, and nanoparticle cancer treatment.
特徴および利点
- Step-by-step microfluidic-based protocols developed and tested by our formulation scientists
- Optimization of drug encapsulation and loading efficiency in nanoparticles and liposomes
- Selection of optimal nanoparticle and liposome size of any size between 100-200 nm
- Small reaction volumes to reduce waste of expensive reagents and therapeutics
法的情報
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Andrew Gdowski et al.
Journal of nanobiotechnology, 16(1), 12-12 (2018-02-13)
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the parameters used in the original formulation must be
Samar Damiati et al.
Genes, 9(2) (2018-02-22)
Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow
Xuanyu Li et al.
Advanced drug delivery reviews, 128, 101-114 (2017-12-27)
Microfluidic chips allow the rapid production of a library of nanoparticles (NPs) with distinct properties by changing the precursors and the flow rates, significantly decreasing the time for screening optimal formulation as carriers for drug delivery compared to conventional methods.
資料
NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.
NanoFabTx™キットは、ナノ粒子・リポソームドラッグデリバリー製剤の迅速かつ十分に制御された合成のために最適化されています。薬物放出挙動が制御された、さまざまな治療薬化合物のカプセル化を行うことができます。
NanoFabTx™DDS製剤プラットフォームは、マイクロ粒子、ナノ粒子またはリポソーム製剤を容易に合成可能なキットです。NanoAssemblr®装置を用いたナノ製剤化事例をご紹介します。
NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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