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About This Item
化学式:
C6H5C6H3(F)CH(CH3)CO2H
CAS番号:
分子量:
244.26
EC Number:
MDL番号:
UNSPSCコード:
12352103
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アッセイ
97%
mp
110-112 °C (lit.)
SMILES記法
CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI
1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChI Key
SYTBZMRGLBWNTM-UHFFFAOYSA-N
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生物化学的／生理学的作用
シクロオキシゲナーゼ（COX）阻害薬；抗真菌活性を有する非ステロイド性抗炎症薬。 Sエナンチオマーはプロスタグランジン合成を阻害し、抗炎症作用および鎮痛作用の両方を有していますが、Rエナンチオマーはプロスタグランジン合成を阻害せず、鎮痛作用のみ示します。
フルルビプロフェンはシクロオキシゲナーゼ（COX）阻害薬であり、プロスタグランジン合成経路における、アラキドン酸からプロスタグランジンG2（PGG2）へ、PGG2からプロスタグランジンH2（PGH2）への変換に関与する酵素です。本化合物は、炎症、疼痛、腫脹および発熱の原因となるプロスタグランジンを減少させます。フルルビプロフェンはCOX-1および-2両方の活性を阻害します。 Sエナンチオマーはプロスタグランジン合成を阻害し、抗炎症作用および鎮痛作用の両方を有していますが、Rエナンチオマーはプロスタグランジン合成を阻害せず、鎮痛作用のみ示します。
以下による置換
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