426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

99%

• 実験式（ヒル表記法）: C₈H₅F₃O₃
• CAS番号: 326-90-9
• 分子量: 206.12
• EC Number: 206-315-1
• MDL番号: MFCD00020935
• UNSPSCコード: 12352100
• PubChem Substance ID: 24866679
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 99%
• フォーム: liquid
• 屈折率: n20/D 1.528 (lit.)
• bp: 203 °C (lit.)
• mp: 19-21 °C (lit.)
• 密度: 1.391 g/mL at 25 °C (lit.)
• 官能基: fluoro; ketone
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)C(=O)CC(=O)c1ccco1
• InChI: 1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2
• InChI Key: OWLPCALGCHDBCN-UHFFFAOYSA-N

詳細

詳細

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated.[1] Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria.[2] Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated.[3] The conformational analysis of the enol and keto form of FTFA has been reported.[4]

アプリケーション

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).[5]
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.[6]
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.[7]
• In the efficient syntheses of perfluoroalkyl substituted azoles.[8]
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.[9]

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 188.6 °F - closed cup
• 引火点(℃): 87 °C - closed cup
• 個人用保護具 (PPE): Eyeshields, Gloves, type ABEK (EN14387) respirator filter