359343

ヒドロキニジン

95%

• 別名: ジヒドロキニジン
• 実験式（ヒル表記法）: C₂₀H₂₆N₂O₂
• CAS番号: 1435-55-8
• 分子量: 326.43
• Beilstein: 91441
• EC Number: 215-862-5
• MDL番号: MFCD00135599
• UNSPSCコード: 12352005
• PubChem Substance ID: 24862070
• NACRES: NA.22

特性

• アッセイ: 95%
• 光学活性: [α]25/D +226°, c = 2 in ethanol
• mp: 169-170 °C (lit.)
• SMILES記法: CC[C@H]1CN2CCC1CC2[C@@H](O)c3ccnc4ccc(OC)cc34
• InChI: 1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1
• InChI Key: LJOQGZACKSYWCH-LHHVKLHASA-N
• 遺伝子情報: human ... CYP2D6(1565)

詳細

詳細

Hydroquinidine, a cinchona alkaloid, is a structural analog of quinidine. It shows antiarrhythmic effect.

アプリケーション

Hydroquinidine can be used as a chiral catalyst to prepare:

• Enantioselective axially chiral phosphamides by N-allylic alkylation reaction between Morita-Baylis-Hillamn (MBH) carbonate and phosphamides.
• Enantioselective α-amino phosphonates by hydrophosphonylation of N-aryl ketimines.
• Enantioselective α-hydrazino esters by α-hydrazination of 3-oxoindolines using azodicarboxylate via aza-Michael reaction.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves