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SMILES記法
Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13
InChI
1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H
InChI Key
VXPCQISYVPFYRK-UHFFFAOYSA-N
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生物化学的／生理学的作用
エトプロパジン塩酸塩はブチリルコリンエステラーゼインヒビターで、抗パーキンソン病薬です。これは、パーキンソン病の特徴である錐体外路運動効果を減少させ、またラットにおいては温熱性痛覚過敏を緩和します。
Kamil Musilek et al.
European journal of medicinal chemistry, 46(2), 811-818 (2011-01-18)
Inhibitors of acetylcholinesterase are compounds widely used in the treatment of various diseases, such as Alzheimer's disease, glaucoma and Myasthenia gravis (MG). Compounds used in the therapy of MG posses a positive charge in the molecule to ensure peripheral effect
Kamil Musilek et al.
Bioorganic & medicinal chemistry letters, 21(1), 150-154 (2010-12-15)
Carbamate inhibitors (e.g., pyridostimine bromide) are used as a pre-exposure treatment for the prevention of organophosphorus poisoning. They work by blocking acetylcholinesterase's (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. However, carbamate inhibitors are known
Marketa Komloova et al.
Bioorganic & medicinal chemistry letters, 21(8), 2505-2509 (2011-03-15)
This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). Their inhibitory (IC(50)) and was compared to the chosen standards ambenonium dichloride, edrophonium chloride, BW284c51
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