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Merck

TEK

TEK tyrosine kinase, endothelial

別名:
CD202B, TIE-2, TIE2, VMCM, VMCM1
Species:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), chicken TEK (427368), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Q02763, A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q5TCU2, Q8IV34
遺伝子ID:
  • Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
  • Mouse(21687) endothelial-specific receptor tyrosine kinase
  • Rat(89804) TEK tyrosine kinase, endothelial
  • chicken(427368) TEK tyrosine kinase, endothelial
  • Zebrafish(30747) TEK tyrosine kinase, endothelial
  • dog(403714) TEK tyrosine kinase, endothelial
  • domestic cat(101091977) TEK tyrosine kinase, endothelial
  • cow(280939) TEK tyrosine kinase, endothelial
  • domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
  • naked mole-rat(101710501) TEK tyrosine kinase, endothelial

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ELISA

製品番号
詳細
Species
RAB0457
Human Tie-2 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
RAB1930
Rat Tie-2 ELISA, for serum, plasma and cell culture supernatants,
Species
rat
RAB1002
Phosphotyrosine TEK / Angiopoietin-1 Receptor ELISA Kit, ,
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
05-584
Anti-Tie2/TEK Antibody, clone Ab33, clone Ab33, Upstate®, from mouse,
交差性
human, mouse, pig, rat
アプリケーション
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4503999
Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunofluorescence
western blot
ABF131
抗リン酸化TIE2/TEK抗体（Tyr992）, 0.25 mg/mL, from rabbit,
交差性
bovine, human, mouse, rat, zebrafish
アプリケーション
immunoprecipitation (IP)
inhibition assay
western blot
SAB1412265
ANTI-TEK antibody produced in mouse, clone 4G9, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
ZRB1645
Anti-Tie-2 Antibody, clone 1C5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
bovine, canine, human, monkey, mouse, rat
アプリケーション
affinity binding assay
immunocytochemistry
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
C8863
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
Species
human

Proteins

製品番号
詳細
Species
14-540-M
Tie2 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.,
Species
human
14-763-M
Tie2 (R849W) Protein, active, 250 µg, ,
Species
human
14-764-M
Tie2 (Y897S) Protein, active, ,
Species
human
SRP5092
TIE2 (771-end)、活性型、GSTタグ融合 ヒト, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
14-763
Tie2 (R849W) Protein, active, 10 µg, ,
Species
human

esiRNA

製品番号
詳細
Species
EMU070911
MISSION® esiRNA, targeting mouse Tek,
Species
mouse
EHU082281
MISSION® esiRNA, targeting human TEK,
Species
human