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Safety Information

S106

Sigma-Aldrich

SR-95531

≥98% (HPLC), powder

Synonym(s):

2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide, Gabazine

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¥41,800
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¥139,000

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10 MG
¥41,800
50 MG
¥139,000

About This Item

Empirical Formula (Hill Notation):
C15H18BrN3O3
CAS Number:
104104-50-9
Molecular Weight:
368.23
MDL number:
MFCD00055135
UNSPSC Code:
12352200
PubChem Substance ID:
24278819
NACRES:
NA.77

¥41,800

Available to ship onApril 07, 2025Details

New, lower price on this item!
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white

solubility

H2O: >10 mg/mL

SMILES string

[Br-].COc1ccc(cc1)-c2ccc(N)[n+](CCCC(O)=O)n2

InChI

1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChI key

GFZHNFOGCMEYTA-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)
rat ... Gabra2(29706)

Biochem/physiol Actions

SR-95531 is a specific GABAA receptor antagonist that does not affect GABA-transaminase or glutamate-decarboxylase activities.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

S106-IP:
S106-50MG:
S106-VAR:
S106-500MG:
S106-10MG:
S106-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000222074
0000222074
0000158055
0000158056

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Ian Duguid et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which
G C Gregoriou et al.
Molecular pharmacology, 98(4), 454-461 (2020-07-02)
Endogenous opioid peptides in the amygdala regulate many of our behaviors and emotional responses. In particular, the endogenous opioid enkephalin plays a significant role in regulating amygdala activity, but its action is strongly limited by peptidases, which degrade enkephalin into
Le Chang et al.
Neuron, 77(3), 559-571 (2013-02-12)
Retinal specializations such as cone-photoreceptor opsin-expression gradients, as found in several vertebrate species, are intuitively considered detrimental to color vision. In mice, the majority of cones coexpress both "blue" and "green" opsin. The coexpression ratio changes along the dorsoventral axis
Yicheng Xie et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(45), 14890-14900 (2014-11-08)
Relatively few studies have examined plasticity of inhibitory neuronal networks following stroke in vivo, primarily due to the inability to selectively monitor inhibition. We assessed the structure of parvalbumin (PV) interneurons during a 5 min period of global ischemia and
Marvin R Diaz et al.
PloS one, 8(1), e55673-e55673 (2013-02-06)
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in CGNs (CGN-I(tonic))
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