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S8753

Sigma-Aldrich

Strychnine hydrochloride

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25 G
¥36,700

¥36,700

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25 G
¥36,700

About This Item

Empirical Formula (Hill Notation):
C21H22N2O2 · HCl
CAS Number:
1421-86-9
Molecular Weight:
370.87
EC Number:
215-826-9
MDL number:
MFCD00058174
UNSPSC Code:
12352210
PubChem Substance ID:
24899812
NACRES:
NA.32

¥36,700

Available to ship onApril 04, 2025Details

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SMILES string

Cl.[H][C@@]12CC(=O)N3c4ccccc4[C@]56CCN7CC(=CCO1)[C@]([H])(C[C@@]57[H])[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19-,20-,21+;/m0./s1

InChI key

VLXYTKMPCOQKEM-ZEYGOCRCSA-N

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Application

Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions.[1][2] It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.[3]

Biochem/physiol Actions

Convulsant; glycine receptor antagonist not associated with the NMDA receptor.
Strychnine is a potent convulsant,[4] which is extracted from Strychnos nux vomica seeds.[5] At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.[6]

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H300 + H330,H410

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

JAN Code

S8753-5G:4548173281650
S8753-VAR:
S8753-BULK:
S8753-25G:4548173211749
S8753-100G:4548173211732

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN1074
MKCN0910
MKCH3395
MKCF3765
MKBZ5674V

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Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity
Bhati R, et al.
Journal of Ayurveda and integrative medicine, 3(2), 80-80 (2012)
Shankai Yin et al.
Hearing research, 237(1-2), 32-48 (2008-02-08)
Neural tuning to sound durations is a useful filter for the identification of a variety of sounds. Previous studies have shown that the interaction between excitatory and inhibitory inputs plays a role in duration selectivity in echolocating bats. However, this
Biomarkers in Toxicology null
Daniel S Borrus et al.
eNeuro, 7(3) (2020-05-13)
The preBötzinger complex (preBötC) gives rise to two types of breathing behavior under normal physiological conditions: eupnea and sighing. Here, we examine the neural mechanisms that couple their underlying rhythms. We measured breathing in awake intact adult mice and recorded
Y-cell receptive field and collicular projection of parasol ganglion cells in macaque monkey retina
Crook JD, et al.
The Journal of Neuroscience, 28(44), 11277-11291 (2008)
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