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A3903

Sigma-Aldrich

1-Aminocyclopropanecarboxylic acid

≥98% (TLC), powder, NMDA agonist

Synonym(s):

ACC, ACPC

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About This Item

Empirical Formula (Hill Notation):
C4H7NO2
CAS Number:
22059-21-8
Molecular Weight:
101.10
Beilstein:
2076413
MDL number:
MFCD00009944
UNSPSC Code:
12352209
PubChem Substance ID:
24890826
NACRES:
NA.32

product name

1-Aminocyclopropanecarboxylic acid, ≥98% (TLC), powder

Quality Level

200

Assay

≥98% (TLC)

form

powder

storage condition

(Keep container tightly closed in a dry and well-ventilated place.
Keep in a dry place.)

color

white

mp

229-231 °C (lit.)

solubility

water: 49.00-51.00 mg/mL, clear, colorless

SMILES string

NC1(CC1)C(O)=O

InChI

1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)

InChI key

PAJPWUMXBYXFCZ-UHFFFAOYSA-N

Gene Information

human ... NARG2(79664)
mouse ... NARG2(93697)
rat ... LOC686240(686240) , NARG2(691379)

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General description

Research area: Cell Signaling

1-Aminocyclopropanecarboxylic acid (ACC) is a non-proteinogenic amino acid and is a member of 1-aminocycloalkanecarboxylic acids.

Application

1-Aminocyclopropanecarboxylic acid (ACC) has been used as a substrate for determining ACC deaminase activity to study the plant growth-promoting characteristics of endophytic isolates obtained from Pteris vittata roots, cucurbit seeds. It has also been used as an ethylene precursor to study the effect of high ethylene concentration on lateral root density (LRD) in sorghum brown midrib (bmr) mutants.

Biochem/physiol Actions

1-Aminocyclopropanecarboxylic acid (ACC) is a partial agonist acting at the N-methyl-D-aspartate (NMDA) receptor glycine modulatory site. ACC serves as a bio-synthetic precursor for the plant hormone ethylene. Therefore, it also plays a vital role in plant development. ACC exhibits anticonvulsant, anxiolytic, anti-addictive, neuroprotective and antidepressant-like effects in rats and mice. ACC does not affect memory or learning processes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A3903-VAR:
A3903-1G:
A3903-100MG:
A3903-250MG-PW:
A3903-1G-PW:
A3903-250MG:
A3903-BULK:
A3903-100MG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sarita Tiwari et al.
Journal of environmental management, 180, 359-365 (2016-06-04)
Mitigation of arsenic (As) pollution is a topical environmental issue of high R&D priority. The present investigation was carried out to isolate As resistant endophytes from the roots of Indian ecotype Pteris vittata and characterize their As transformation and tolerance
Valentin Marquis et al.
Plant, cell & environment, 43(6), 1558-1570 (2020-03-13)
Jasmonate synthesis and signalling are essential for plant defense upregulation upon herbivore or microbial attacks. Stress-induced accumulation of jasmonoyl-isoleucine (JA-Ile), the bioactive hormonal form triggering transcriptional changes, is dynamic and transient because of the existence of potent removal mechanisms. Two
1-Aminocyclopropanecarboxylic acid (ACPC) produces procognitive but not antipsychotic-like effects in rats
Popik P, et al.
Psychopharmacology, 232(6), 1025?1038-1025?1038 (2000)
Livia Merendino et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 375(1801), 20190567-20190567 (2020-05-05)
The early steps in germination and development of angiosperm seedlings often occur in the dark, inducing a special developmental programme called skoto-morphogenesis. Under these conditions photosynthesis cannot work and all energetic requirements must be fulfilled by mitochondrial metabolization of storage
Y A Kolesnikov et al.
Life sciences, 55(18), 1393-1398 (1994-01-01)
1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence
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