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34078

Supelco

Oxyclozanide

VETRANAL®, analytical standard

Synonym(s):

2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide, 3,3′,5,5′,6-Pentachloro-2′-hydroxysalicylanilide

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About This Item

Empirical Formula (Hill Notation):
C13H6Cl5NO3
CAS Number:
2277-92-1
Molecular Weight:
401.46
EC Number:
218-904-0
MDL number:
MFCD00864507
UNSPSC Code:
41116107
PubChem Substance ID:
329754798
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Oc1c(Cl)cc(Cl)cc1NC(=O)c2c(O)c(Cl)cc(Cl)c2Cl

InChI

1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)

InChI key

JYWIYHUXVMAGLG-UHFFFAOYSA-N

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General description

Oxyclozanide is an anthelmintic agent, which can show activity against Fasciola hepatica, a parasitic trematode and hence, can be used in the treatment of liver fluke infections.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

34078-BULK:
34078-100MG:
34078-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK0517
BCCJ3689
BCCD2132
BCCC1795
BCBV2215

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S A Spence et al.
Australian veterinary journal, 69(9), 217-220 (1992-09-01)
A significant increase in milk production, averaging 164 litres per cow per lactation (a 4.8% increase), was seen after cows infected with gastrointestinal nematodes, paramphistomes and Fasciola hepatica were treated with broad-spectrum anthelmintics. Three hundred and ninety pairs of cows
E E Guobadia et al.
Veterinary parasitology, 68(3), 269-282 (1997-02-01)
The 17kDa and 69kDa polypeptide antigens which are specific to Fasciola gigantica were excised from polyacrylamide gels and used for the immunization of rabbits to raise monospecific antisera against these polypeptides. These sera were labelled with horseradish peroxidase and used
C Paraud et al.
Veterinary journal (London, England : 1997), 180(2), 265-267 (2008-03-04)
Paramphistome infections are very common in ruminants and may induce clinical signs, but little is known about effective treatments. In this study, the efficacy of oxyclozanide against Calicophoron daubneyi was studied in goats and its activity tested against immature stages
Treatment of Dicrocoelium dendriticum with a combination of thiophanate and brotianide.
B Tinar et al.
The Veterinary record, 123(25), 650-651 (1988-12-17)
N A Mohammed-Ali et al.
Journal of veterinary pharmacology and therapeutics, 10(2), 127-133 (1987-06-01)
The pharmacokinetics of oxyclosanide, rafoxanide and closantel were investigated in sheep (n = 5). All three drugs were extensively (greater than 99%) bound to plasma proteins and the plasma concentration/time curve was best described by a tri-exponential equation. Closantel and
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