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34042

Supelco

Rafoxanide

PESTANAL®, analytical standard

Synonym(s):

3′-Chloro-4′-(4-chlorophenoxy)-3,5-diiodosalicylanilide

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About This Item

Empirical Formula (Hill Notation):
C19H11Cl2I2NO3
CAS Number:
Molecular Weight:
626.01
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

PESTANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

SMILES string

Oc1c(I)cc(I)cc1C(=O)Nc2ccc(Oc3ccc(Cl)cc3)c(Cl)c2

InChI

1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)

InChI key

NEMNPWINWMHUMR-UHFFFAOYSA-N

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General description

Rafoxanide is a halogenated salicylanilide and an anthelmintic agent. It is widely used against fasciolosis and haemonchosis in sheep and cattle. It also finds applications as an adulticide for Fasciola hepatica and Fasciola gigantica.

Application

Rafoxanide may be used as a reference standard in the determination of rafoxanide in plasma and tissue samples using high-performance liquid chromatography (HPLC) coupled with an ultraviolet detector and thermospray − mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

34042-VAR-R:
34042-100MG-R:4548173354170
34042-BULK-R:


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M Atef et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(12), 3340-3344 (2010-09-25)
The pharmacokinetic aspects of florfenicol (FLO) were investigated via intravenous (I.V.) and intramuscular (I.M.) injections in five goats at a dose of 20 mg kg(-1) b.wt. Animals were pre-treated with albendazole orally in a dose of 2.5 mg kg(-1) b.wt
J H Gill et al.
International journal for parasitology, 25(4), 463-470 (1995-04-01)
Avermectin (AVM) inhibition of the development of the free-living stages of Haemonchus contortus has been quantified in an assay in which nematode eggs are placed on an agar matrix containing serial dilutions of a drug in the wells of a
C P Swarnkar et al.
Tropical animal health and production, 33(4), 305-312 (2001-07-28)
Monitoring anthelmintic resistance in strongyle nematodes by the faecal egg count reduction test and a commercial larval development assay on an organized sheep farm in the semi-arid area of Rajasthan revealed the emergence of resistance to benzimidazoles and rafoxanide and
C M Miller et al.
International journal for parasitology, 24(4), 533-542 (1994-07-01)
A possible link between the level of glutathione S-transferase (GST, E.C. 2.5.1.18) activity and the development of salicylanilide resistance in Fasciola hepatica was investigated. Various isolates of F. hepatica with varying susceptibilities to salicylanilides were isolated and maintained in the
H A El-Banna et al.
Parasitology research, 102(6), 1337-1342 (2008-02-26)
This study investigated the comparative serum disposition kinetics of ivermectin (IVM) after a single subcutaneous dose of 200 microg/kg body weight of IVM alone or in combination with an anthelmintic consisting of ivermectin and rafoxanide (200 microg/kg of IVM and

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