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Role of Cl

The Journal of physiology (2016-06-30)
Ahlam I Salameh, Christian A Hübner, Walter F Boron
ABSTRACT

A polymorphism of human AE3 is associated with idiopathic generalized epilepsy. Knockout of AE3 in mice lowers the threshold for triggering epileptic seizures. The explanations for these effects are elusive. Comparisons of cells from wild-type vs. AE3 The anion exchanger AE3, expressed in hippocampal (HC) neurons but not astrocytes, contributes to intracellular pH (pH

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