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In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

Nanoscale (2014-12-23)

Ana Sousa-Herves, Christian Sánchez Espinel, Amir Fahmi, África González-Fernández, Eduardo Fernandez-Megia

ABSTRACT

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.

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Bicarbonato di sodio, ACS reagent, ≥99.7%

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Bromuro di potassio, FT-IR grade, ≥99% trace metals basis

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Bicarbonato di sodio, powder, BioReagent, for molecular biology, suitable for cell culture, suitable for insect cell culture

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tert-Butanol, ACS reagent, ≥99.0%

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Bicarbonato di sodio, ReagentPlus^®, ≥99.5%, powder

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(+)- L-ascorbato di sodio, crystalline, ≥98%

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Bromuro di potassio, ACS reagent, ≥99.0%

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Bicarbonato di sodio, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99.7%

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(+)- L-ascorbato di sodio, BioXtra, ≥99.0% (NT)

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(+)- L-ascorbato di sodio, powder, BioReagent, suitable for cell culture

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tert-Butanol, suitable for HPLC, ≥99.5%

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tert-Butanol, ≥99% (GC)

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Acido fenilacetico, 99%

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Bromuro di potassio, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99%

USP

Bicarbonato di sodio, United States Pharmacopeia (USP) Reference Standard

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4-Pentynoic acid, 95%

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tert-Butanol, TEBOL^® 99, ≥99.3%

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tert-Butanol, anhydrous, ≥99.5%

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Acido fenilacetico, ≥99%, FCC, FG

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Bromuro di potassio, BioUltra, ≥99.5% (AT)

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Bicarbonato di sodio, BioXtra, 99.5-100.5%

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(+)- L-ascorbato di sodio, Pharmaceutical Secondary Standard; Certified Reference Material

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Bicarbonato di sodio, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99.5%

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Bromuro di potassio, anhydrous, powder, 99.999% trace metals basis

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Bromuro di potassio, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99%

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tert-Butanol, analytical standard

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Bicarbonato di sodio, tested according to Ph. Eur.