V900286
2-Aminopyrimidine
Vetec™, reagent grade, 97%
Sinonimo/i:
2-Pyrimidinamine
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About This Item
Formula empirica (notazione di Hill):
C4H5N3
Numero CAS:
Peso molecolare:
95.10
Beilstein:
107014
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
Prezzi e disponibilità al momento non sono disponibili
Grado
reagent grade
Nome Commerciale
Vetec™
Saggio
97%
Punto di fusione
122-126 °C (lit.)
Stringa SMILE
Nc1ncccn1
InChI
1S/C4H5N3/c5-4-6-2-1-3-7-4/h1-3H,(H2,5,6,7)
LJXQPZWIHJMPQQ-UHFFFAOYSA-N
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Note legali
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Ye-Xiang Xie et al.
The Journal of organic chemistry, 71(21), 8324-8327 (2006-10-10)
Efficient and solvent-free copper-catalyzed N-arylations of imidazoles with aryl and heteroaryl halides have been demonstrated. In the presence of CuBr, 2-aminopyrimidine-4,6-diol, and TBAF (n-Bu4NF), a variety of imidazoles underwent the N-arylation reaction with aryl and heteroaryl halides smoothly in moderate
Nicholas R Perl et al.
Journal of the American Chemical Society, 132(6), 1802-1803 (2010-01-26)
A convergent synthesis of (-)-crambidine is reported. The sequence capitalizes on two novel key transformations, including a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hydroamination employing 2-aminopyrimidine nucleophiles.
Kamaljit Singh et al.
European journal of medicinal chemistry, 52, 82-97 (2012-03-31)
2-Aminopyrimidine based 4-aminoquinolines were synthesized using an efficacious protocol. Some of the compounds showed in vitro anti-plasmodial activity against drug-sensitive CQ(S) (3D7) and drug-resistant CQ(R) (K1) strains of Plasmodium falciparum in the nM range. In particular, 5-isopropyloxycarbonyl-6-methyl-4-(2-nitrophenyl)-2-[(7-chloroquinolin-4-ylamino)butylamino] pyrimidine depicted the lowest
Manuel Tzouros et al.
Chemical research in toxicology, 22(5), 853-862 (2009-03-26)
Covalent binding of reactive metabolites is generally accepted as one underlying mechanism of drug-induced toxicity. However, identification of protein targets by reactive metabolites still remains a challenge due to their low abundance. Here, we report the development of a highly
Jinho Lee et al.
Bioorganic & medicinal chemistry letters, 21(14), 4203-4205 (2011-06-21)
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of
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