SRP5346

CyclinC, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Sinonimo/i: CCNC, CycC
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Ricombinante: expressed in baculovirus infected Sf9 cells
• Saggio: ≥70% (SDS-PAGE)
• Stato: buffered aqueous glycerol solution
• PM: ~55 kDa
• N° accesso NCBI: NM_005190
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... CCNC(892)

Descrizione

Descrizione generale

Cyclin C is a member of the cyclin family of proteins. The gene encoding it is localized on human chromosome 6q16.2.[1]

Azioni biochim/fisiol

Cyclin C interacts with the cyclin-dependent kinase 8 (CDK8)[2] and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The mRNA levels of Cyclin C fluctuate during the cell cycle and peak at the G1 phase. Cyclin C acts as a critical regulator of the G0/G1 transition of human hematopoietic stem cells.[3] Cyclin C can also associate with CDK3 to enhance retinoblastoma phosphorylation at S807/811 during the G0/G1 transition,[4] and this phosphorylation is required for cells to exit G0 efficiently.

Stato fisico

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Nota sulla preparazione

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable