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Merck
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Documenti

SML3242

Sigma-Aldrich

MR6-31-2

≥98% (HPLC)

Sinonimo/i:

2-(4-Chlorobenzyl)benzo[d][1,2]selenazol-3(2H)-one, 2-[(4-Chlorophenyl)methyl]-1,2-benzisoselenazol-3(2H)-one

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About This Item

Formula empirica (notazione di Hill):
C14H10ClNOSe
Numero CAS:
2524641-00-5
Peso molecolare:
322.65
Codice UNSPSC:
12352107
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1N(CC2=CC=C(Cl)C=C2)[Se]C3=CC=CC=C31

Azioni biochim/fisiol

MR6-31-2, a CNS penetrant ebselen analog, is a potent inhibitor of SARS-CoV-2 Mpro that bind at the Mpro catalytic site. MR6-31-2 donates a selenium atom, forming a covalent bond and blocking the histidine-Cys catalytic dyad. It exhibits good neuroprotective effects and low cytotoxicity in cell-based and mouse models of motor neuron disease. MR6-31-2 covalently binds to A4V superoxide dismutase-1 (SOD1) and promotes its thermal stability.

Avvertenze

Danger

Indicazioni di pericolo

H301 + H331,H373,H410

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Kangsa Amporndanai et al.
Nature communications, 12(1), 3061-3061 (2021-05-26)
The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (Mpro), critical for viral replication, is a key target for therapeutic development. An organoselenium drug called ebselen has been demonstrated to have potent Mpro inhibition and
Varunya Chantadul et al.
Communications biology, 3(1), 97-97 (2020-03-07)
Mutations to the gene encoding superoxide dismutase-1 (SOD1) were the first genetic elements discovered that cause motor neuron disease (MND). These mutations result in compromised SOD1 dimer stability, with one of the severest and most common mutations Ala4Val (A4V) displaying
Kangsa Amporndanai et al.
Nature communications, 12(1), 3061-3061 (2021-05-26)
The SARS-CoV-2 pandemic has triggered global efforts to develop therapeutics. The main protease of SARS-CoV-2 (Mpro), critical for viral replication, is a key target for therapeutic development. An organoselenium drug called ebselen has been demonstrated to have potent Mpro inhibition and
Varunya Chantadul et al.
Communications biology, 3(1), 97-97 (2020-03-07)
Mutations to the gene encoding superoxide dismutase-1 (SOD1) were the first genetic elements discovered that cause motor neuron disease (MND). These mutations result in compromised SOD1 dimer stability, with one of the severest and most common mutations Ala4Val (A4V) displaying

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