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Merck
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SML2141

Sigma-Aldrich

Solifenacin succinate

≥98% (HPLC)

Sinonimo/i:

(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4­dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate succinate, YM905

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About This Item

Formula empirica (notazione di Hill):
C23H26N2O2 · C4H6O4
Numero CAS:
242478-38-2
Peso molecolare:
480.55
Numero MDL:
MFCD00954234
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Attività ottica

[α]/D +35 to +45°, c = 1 in H2O

Condizioni di stoccaggio

desiccated

Colore

white to beige

Solubilità

H2O: 2 mg/mL, clear

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(CCC(O)=O)=O.O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3

InChI

1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21?,22-;/m0./s1
RXZMMZZRUPYENV-DZSUWJOWSA-N

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Azioni biochim/fisiol

Solifenacin succinate (SOL) blocks the cholinergic signals to M3 receptors by inhibiting the muscarinic M3 receptors in the bladder. This action prevents the contractions of the detrusor muscles in the urinary bladder wall, leading to relaxing the bladder as well as decreasing urinary urgency and nocturia. Thus, SOL is a widely used antimuscarinic agent for treating the contraction of the overactive bladder.

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H361d

Classi di pericolo

Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Donald Newgreen et al.
The Journal of urology, 198(4), 928-936 (2017-05-17)
We evaluated the long-term safety and efficacy of once daily oral solifenacin suspension in children (5 to less than 12 years old) and adolescents (12 to less than 18 years old) with overactive bladder. We conducted a 40-week, open label extension
Molecular docking of different ionophores host-guest inclusion complexes for electrochemical determination of solifenacin succinate in pure and pharmaceutical dosage form: Computer aided design
Eissa MS, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 159, 105363-105363 (2020)
Stability-indicating HPTLC method for the simultaneous detection and quantification of alfuzosin hydrochloride, solifenacin succinate along with four of their official impurities
Tantawy MA, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 157, 104905-104905 (2020)
Yoshihiko Ito et al.
Biological & pharmaceutical bulletin, 39(7), 1167-1171 (2016-07-05)
Solifenacin is an antimuscarinic agent used to treat symptoms of overactive bladder. Pharmacologically significant amounts of solifenacin were excreted in the urine of humans taking a clinical dose of this drug. The aim of this study is to measure muscarinic
Tomomi Oki et al.
British journal of pharmacology, 145(2), 219-227 (2005-03-09)
1 A novel muscarinic receptor antagonist, solifenacin succinate, inhibited specific binding of [N-methyl-(3)H]-scopolamine ([(3)H]-NMS) in the mouse bladder, submaxillary gland and heart in a concentration-dependent manner. This inhibitory effect was greatest in the submaxillary gland, followed by the bladder and

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